{"id":14538,"date":"2023-09-29T17:24:00","date_gmt":"2023-09-29T08:24:00","guid":{"rendered":"https:\/\/www.acacia-no-ki.co.jp\/wellness\/?p=14538"},"modified":"2023-12-14T12:55:52","modified_gmt":"2023-12-14T03:55:52","slug":"genotype-of-alcohol-resistance","status":"publish","type":"post","link":"https:\/\/www.acacia-no-ki.co.jp\/wellness\/genotype-of-alcohol-resistance\/","title":{"rendered":"\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5f37\u3044\u3001\u5f31\u3044\u306f\u907a\u4f1d\u5b50\u306e\u914d\u5217\u306b\u3088\u3063\u3066\u9055\u3046\u3063\u3066\u30a6\u30bd\uff1f\u30db\u30f3\u30c8\uff1f"},"content":{"rendered":"

\u30a2\u30ab\u30b7\u30a2\u306e\u6a39Q<\/span>\uff06A<\/span>\u30b7\u30ea\u30fc\u30ba\uff5e\u5065\u5eb7\u306b\u95a2\u3059\u308b\u300c\u30a6\u30ef\u30b5\u306e\u771f\u76f8\u300d\uff5e<\/p>\n

\u7b2c15<\/span>\u56de\u3000\u30a2\u30eb\u30b3\u30fc\u30eb\u3068\u907a\u4f1d\u5b50\u306b\u95a2\u3059\u308b\u30a6\u30ef\u30b5\u306e\u771f\u76f8<\/p>\n

\u4f53\u8cea\u7684\u306b\u307e\u3063\u305f\u304f\u304a\u9152\u304c\u98f2\u3081\u306a\u3044\u3001\u3082\u3057\u304f\u306f\u5c11\u91cf\u3057\u304b\u98f2\u3081\u306a\u3044\u4eba\u306e\u3053\u3068\u3092\uff62\u4e0b\u6238\uff08\u3052\u3053\uff09\uff63\u3068\u547c\u3073\u307e\u3059\u3002\u3053\u306e\u4e0b\u6238\u3068\u3044\u3046\u8a00\u8449\u306f1300<\/span>\u5e74\u524d\u3001\u98db\u9ce5\u6642\u4ee3\u304b\u3089\u4f7f\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u6614\u304b\u3089\u304a\u9152\u306b\u5f31\u3044\u4eba\u304c\u5b58\u5728\u3059\u308b\u3068\u3044\u3046\u8a8d\u8b58\u306f\u3042\u3063\u305f\u3088\u3046\u3067\u3059\u3002\u6700\u8fd1\u3067\u306f\u3053\u306e\u304a\u9152\u304c\u98f2\u3081\u306a\u3044\u4eba\u306f\u5148\u5929\u7684\u306b\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u9055\u3044\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n

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(\u8cea\u554f\u306b\u5bfe\u3059\u308b\u30a2\u30f3\u30b5\u30fc\u306b\u3064\u3044\u3066\u306f\u30a2\u30ab\u30b7\u30a2\u306e\u6a39\u516c\u5f0f\u30c4\u30a4\u30c3\u30bf\u30fc\u306b\u3066\u30a2\u30f3\u30b1\u30fc\u30c8\u5f62\u5f0f\u3067\u6295\u7968\u3067\u304d\u307e\u3059\u3002\u30b3\u30c1\u30e9\u304b\u3089\u3002<\/a>)<\/strong><\/p>\n

\u2192\u30db\u30f3\u30c8\uff08\u4fe1\u983c\u6027\u2605\u2605\u2605\u2605\u2606\uff09\uff1a\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306b\u3064\u3044\u3066\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u304c\u95a2\u9023\u3057\u307e\u3059\u3002\u3053\u306e\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u306e\u914d\u5217\u306f\u7279\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u578b\u306e\u9055\u3044\u306b\u3088\u308a\u4f5c\u3089\u308c\u308b\u9175\u7d20\u306e\u30a2\u30df\u30ce\u9178\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306b\u3088\u308a\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u5206\u89e3\u80fd\u529b\u306b\u9055\u3044\u304c\u51fa\u307e\u3059\u3002<\/p>\n

1.\u3000\u4eba\u306e\u4f53\u8cea\u306f\u5148\u5929\u7684\u306a\u8981\u7d20\u3068\u5f8c\u5929\u7684\u306a\u8981\u7d20\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b<\/h3>\n

 <\/p>\n

\u304a\u9152\u306b\u304b\u304e\u3089\u305a\u3001\u85ac\u3084\u98df\u54c1\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u306f\u4eba\u305d\u308c\u305e\u308c\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u500b\u4eba\u306b\u3088\u308b\u53cd\u5fdc\u306e\u9055\u3044\u3001\u3044\u308f\u3086\u308b\u300c\u4f53\u8cea\u300d\u306f\u907a\u4f1d\u306b\u3088\u308b\u5148\u5929\u7684\u306a\u3082\u306e\u3068\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3084\u74b0\u5883\u8981\u56e0\u306e\u3088\u3046\u306a\u5f8c\u5929\u7684\u306a\u3082\u306e\u304c\u5f71\u97ff\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u304a\u9152\u306e\u5f37\u3055\uff08\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\uff09\u306b\u3064\u3044\u3066\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u304c\u95a2\u9023\u3057\u307e\u3059\u3002\u3053\u306e\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u306e\u914d\u5217\u306b\u3064\u3044\u3066\u3082\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u00a0<\/span>\u4eca\u56de\u306f\u907a\u4f1d\u5b50\u306e\u3053\u3068\u306b\u89e6\u308c\u306a\u304c\u3089\u304a\u9152\u306b\u5f37\u3044\u4eba\u3001\u5f31\u3044\u306e\u4eba\u306e\u4f53\u8cea\u306b\u3064\u3044\u3066\u7d10\u89e3\u3044\u3066\u307f\u3088\u3046\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u00a02. \u907a\u4f1d\u5b50\u306e\u3053\u3068\u77e5\u3063\u3066\u3044\u307e\u3059\u304b\uff1f\u307e\u305a\u306f\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u7c21\u5358\u306b\u89e3\u8aac<\/span><\/h3>\n

\u304a\u9152\u3068\u907a\u4f1d\u5b50\u306e\u89e3\u8aac\u306e\u524d\u306b\u3001\u308f\u304b\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u96e3\u3057\u3044\u907a\u4f1d\u5b50\u306e\u3053\u3068\u3092\u7c21\u5358\u306b\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n

\u907a\u4f1d\u5b50\u3001\u3053\u306e\u8a00\u8449\u3092\u805e\u3044\u305f\u3053\u3068\u306e\u306a\u3044\u4eba\u306f\u3044\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u30b2\u30ce\u30e0\u3001\u907a\u4f1d\u5b50\u3001DNA<\/span>\u2026\u4f55\u3068\u306a\u304f\u4f3c\u305f\u30a4\u30e1\u30fc\u30b8\u306e\u8a00\u8449\u3082\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u8a18\u4e8b\u3092\u6a5f\u4f1a\u306b\u6574\u7406\u3057\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n

2-1. \u907a\u4f1d\u5b50\u3068\u306f\u751f\u7269\u306e\u8a2d\u8a08\u56f3<\/h4>\n

\u907a\u4f1d\u5b50\u306f\u3001\u751f\u7269\u304c\u751f\u304d\u3066\u3044\u304f\u3046\u3048\u3067\u5fc5\u8981\u306a\u60c5\u5831\u3092\u4fdd\u6301\u3057\u4f1d\u9054\u3059\u308b\u305f\u3081\u306e\u56e0\u5b50\u3067\u3059\u3002\u305d\u3057\u3066\u3053\u306e\u907a\u4f1d\u5b50\u3068\u3044\u3046\u5f79\u5272\u306fDNA<\/span>\uff08\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u6838\u9178\uff09\u3068\u3044\u3046\u5206\u5b50\u304c\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\uff08\u53b3\u5bc6\u306b\u306fDNA<\/span>\u4ee5\u5916\u306e\u5206\u5b50\u3082\u907a\u4f1d\u5b50\u3068\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\uff09\u907a\u4f1d\u5b50\u306f\u751f\u7269\u306e\u8a2d\u8a08\u56f3\u3068\u30a4\u30e1\u30fc\u30b8\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u305d\u3057\u3066\u3001\u907a\u4f1d\u5b50\u5168\u4f53\u306e\u3053\u3068\u3092\u30b2\u30ce\u30e0\u3068\u3044\u3044\u307e\u3059\u3002\u30d2\u30c8\u3092\u542b\u3081\u591a\u304f\u306e\u751f\u7269\u306f\u4e21\u89aa\u304b\u30891<\/span>\u30bb\u30c3\u30c8\u305a\u3064\u306e\u30b2\u30ce\u30e0\u3092\u53d7\u3051\u7d99\u3050\u306e\u3067\uff12\u3064\u306e\u30b2\u30ce\u30e0\u30bb\u30c3\u30c8\u3092\u3082\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

2-2. \u907a\u4f1d\u5b50\u3001DNA<\/span>\u306e\u8a2d\u8a08\u56f3\u3092\u3082\u3068\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u308b<\/h4>\n

\u907a\u4f1d\u5b50\u306f\u751f\u7269\u306e\u8a2d\u8a08\u56f3\u3068\u30a4\u30e1\u30fc\u30b8\u3057\u3066\u304f\u3060\u3055\u3044\u3068\u66f8\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u8a2d\u8a08\u56f3\u306fDNA<\/span>\u3068\u3044\u3046\u8a00\u8449\u3067\u66f8\u304b\u308c\u3066\u304a\u308a\u3001\u4f7f\u3046\u6587\u5b57\u306f\u305f\u3063\u305f\uff14\u3064\u3067\u3059\u3002\u6b63\u3057\u304f\u8aac\u660e\u3059\u308b\u3068\u3001DNA<\/span>\u306f\u4e8c\u672c\u306e\u3089\u305b\u3093\u72b6\u306e\u9396\u69cb\u9020\u306e\u5206\u5b50\u3067\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u9396\u306f\u305f\u3063\u305f4\u3064\u306e\u5869\u57fa\uff08\u30a2\u30c7\u30cb\u30f3\u3001\u30b7\u30c8\u30b7\u30f3\u3001\u30b0\u30a2\u30cb\u30f3\u3001\u30c1\u30df\u30f3\uff09\u306e\u7d44\u307f\u5408\u308f\u305b\u304b\u3089\u6210\u308a\u7acb\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u907a\u4f1d\u5b50\u3084DNA<\/span>\u306f\u8a2d\u8a08\u56f3\u3068\u3057\u3066\u306e\u60c5\u5831\u306a\u306e\u3067\u3053\u308c\u3060\u3051\u3067\u306f\u6a5f\u80fd\u3057\u307e\u305b\u3093\u3002\u8a2d\u8a08\u56f3\u3092\u3082\u3068\u306b\u751f\u547d\u6d3b\u52d5\u306b\u5fc5\u8981\u306a\u30a2\u30df\u30ce\u9178\u3092\u96c6\u3081\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308a\u51fa\u3057\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7d30\u80de\u306e\u69cb\u7bc9\u3068\u6a5f\u80fd\u306b\u95a2\u308f\u308b\u7269\u8cea\u3067\u3059\u3002\u79c1\u305f\u3061\u306e\u4f53\u3092\u4f5c\u308b\u7b4b\u8089\u3084\u4f53\u5185\u306e\u9175\u7d20\u3001\u30db\u30eb\u30e2\u30f3\u3001\u6297\u4f53\u306a\u3069\u3001\u307b\u3068\u3093\u3069\u306e\u751f\u7269\u5b66\u7684\u306a\u6a5f\u80fd\u306e\u591a\u304f\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u50cd\u304d\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002<\/p>\n

\"\"<\/p>\n

 <\/p>\n

 <\/p>\n

\u56f3\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b50\u306f\u8a2d\u8a08\u56f3\u3001\u30a2\u30df\u30ce\u9178\u306f\u7d20\u6750\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30d1\u30fc\u30c4\u3068\u30a4\u30e1\u30fc\u30b8\u3059\u308b\u3068\u7406\u89e3\u3057\u3084\u3059\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u00a03<\/span>. \u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u4ee3\u8b1d\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50<\/h3>\n

3-1. \u30a2\u30eb\u30b3\u30fc\u30eb\u306f\u3001\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d20\uff08ALDH<\/span>\uff09\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u308b<\/h4>\n

\u4eca\u56de\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\uff08\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3068\u305d\u306e\u907a\u4f1d\u5b50\uff08DNA<\/span>\u914d\u5217\uff09\u306e\u8a71\u3067\u3059\u3002\uff08\u907a\u4f1d\u5b50\u3084DNA<\/span>\u306e\u8a71\u306a\u3069\u524d\u7f6e\u304d\u304c\u9577\u304f\u306a\u3063\u3066\u3057\u3044\u307e\u3057\u305f\uff09\u3002\u4ee5\u524d\u3001\u5c11\u3057\u306e\u98f2\u9152\u306f\u5065\u5eb7\u306b\u826f\u3044\u52b9\u679c\u304c\u3042\u308b\u3063\u3066\u30a6\u30bd\uff1f\u30db\u30f3\u30c8\uff1f<\/a>\u3000\u306e\u8a18\u4e8b\u3067\u4f53\u5185\u3067\u30a2\u30eb\u30b3\u30fc\u30eb\u304c\u5206\u89e3\uff08\u4ee3\u8b1d\uff09\u3055\u308c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/p>\n

 <\/p>\n

 <\/p>\n

\u7c21\u5358\u306b\u8aac\u660e\u3059\u308b\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5927\u534a\u306f\u3001\u809d\u81d3\u30672<\/span>\u6bb5\u968e\u53cd\u5fdc\u306b\u3088\u3063\u3066\u5206\u89e3\uff08\u4ee3\u8b1d\uff09\u3055\u308c\u307e\u3059\u3002\u307e\u305a\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u8131\u6c34\u7d20\u9175\u7d20\uff08ADH<\/span>\uff09\u306e\u50cd\u304d\u306b\u3088\u3063\u3066\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u3001\u305d\u3057\u3066\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d20\uff08ALDH<\/span>\uff09\u306e\u50cd\u304d\u306b\u3088\u3063\u3066\u9162\u9178\u3078\u3068\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u00a0<\/span><\/p>\n

3-2. ALDH2<\/span>\u306e\u50cd\u304d\u304c\u304a\u9152\u306e\u5f37\u3055\u306b\u5927\u304d\u304f\u95a2\u4e0e<\/h4>\n

\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u3082\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u9154\u3046\u539f\u56e0\u7269\u8cea\u3068\u306a\u308b\u306e\u3067\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u4ee3\u8b1d\u3059\u308b\u306b\u306f\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d20\u3001ALDH<\/span>\u306e\u50cd\u304d\u304c\u5927\u4e8b\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d20\uff08ALDH<\/span>\uff09\u306e\u4e2d\u306b\u3082\u5927\u304d\u304f\uff12\u7a2e\u985e\u306e\u9175\u7d20\u304c\u3042\u308a\u3001ALDH<\/span>\uff12\u306e\u65b9\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306b\u306f\u5927\u304d\u304f\u95a2\u4e0e\u3057\u307e\u3059\u3002\uff08\uff12\uff09<\/p>\n

ALDH1<\/span>\u306f\u8840\u4e2d\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u3063\u3066\u304b\u3089\u4f5c\u7528\u304c\u59cb\u307e\u308a\u3001\u3086\u3063\u304f\u308a\u5206\u89e3\u3059\u308b\u9175\u7d20\u3002ALDH2<\/span>\u306f\u8840\u4e2d\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u304c\u4f4e\u3044\u6642\u70b9\u304b\u3089\u4f5c\u7528\u3059\u308b\u5f37\u529b\u306a\u9175\u7d20\u3002\u304a\u9152\u304c\u5f37\u3044\u4eba\u3068\u5f31\u3044\u4eba\u306e\u5dee\u306f\u3001\u3053\u3061\u3089\u306eALDH2<\/span>\u578b\u306e\u9175\u7d20\u6d3b\u6027\u306e\u5f37\u3055\u306b\u3088\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u00a04<\/span>. \u304a\u9152\u306b\u5f37\u3044\u4eba\u3001\u5f31\u3044\u306e\u4eba\u306e\u907a\u4f1d\u5b50\u578b\u3068\u306f\uff1f<\/h3>\n

4-1. \u305f\u3063\u305f\u3072\u3068\u3064\u306eALDH2<\/em>\u306e\u907a\u4f1d\u5b50\u914d\u5217\u304c\u9175\u7d20\u6d3b\u6027\u3092\u5927\u304d\u304f\u5909\u3048\u308b<\/h4>\n

ALDH2<\/span>\u306f\u8840\u4e2d\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u304c\u4f4e\u3044\u6642\u70b9\u304b\u3089\u4f5c\u7528\u3059\u308b\u5f37\u529b\u306a\u9175\u7d20\u3067\u3059\u3002<\/p>\n

\u305d\u3057\u3066ALDH2<\/em>\u306f\u3001\u907a\u4f1d\u5b50\u306e\u5869\u57fa\u914d\u5217\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u9175\u7d20\u6d3b\u6027\u306e\u5f37\u3044\u3082\u306e\u3068\u6d3b\u6027\u5f31\u3044\u3082\u306e\u304c\u3042\u308b\u3068\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

4-2. 487<\/span>\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u304b\u3089\u30ea\u30b8\u30f3\u306b\u5909\u308f\u308b\u3068\u5f31\u304f\u306a\u308b<\/h4>\n

\"\"<\/p>\n

 <\/p>\n

ALDH2<\/span><\/em>\u306e\u8a2d\u8a08\u56f3\u306b\u66f8\u304b\u308c\u3066\u3044\u308bDNA<\/span>\u914d\u5217\u306e112241766<\/span>\u756a\u76ee\u306e\u5869\u57fa\u304c\u300cG(<\/span>\u30b0\u30a2\u30cb\u30f3)<\/span>\u300d\u306e\u5834\u5408\u3001ALDH2<\/span>\u9175\u7d20\u306e487<\/span>\u203b\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u306f\u300c\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u300d\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u907a\u4f1d\u5b50\u304b\u3089\u4f5c\u3089\u308c\u308bALDH2<\/span>\u306f\u9ad8\u6d3b\u6027\u578b\uff08\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u5206\u89e3\u3059\u308b\u6d3b\u6027\u304c\u9ad8\u3044\uff09\u3068\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001\u4ed6\u306e\u4eba\u306f\u540c\u3058\u8a2d\u8a08\u56f3\u3067\u3082112241766<\/span>\u756a\u76ee\u306e\u5869\u57fa\u304c\u300cA(<\/span>\u30a2\u30c7\u30cb\u30f3)<\/span>\u300d\u3068\u306a\u308b\u3068\u3001\u30a2\u30df\u30ce\u9178\u306f\u300c\u30ea\u30b8\u30f3\u300d\u3068\u306a\u308a\u3001\u3053\u306eALDH2<\/span>\u9175\u7d20\u306f\u6d3b\u6027\u304c\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u540c\u3058ALDH\uff12<\/em>\u3067\u3082\u907a\u4f1d\u5b50\u914d\u5217\u304c\u9055\u3046\u3068\u7570\u306a\u308b\u30a2\u30df\u30ce\u9178\u3068\u306a\u308a\u3001ALDH<\/span>\uff12\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u306b\u80fd\u529b\u306e\u5dee\u304c\u3067\u304d\u308b\u306e\u3067\u3059\uff08\uff11\uff09\u3002<\/p>\n

\uff08\u203b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u6210\u719f\u3057\u305f\u72b6\u614b\u3060\u3068487 <\/span>\u756a\u76ee\u3001\u524d\u99c6\u4f53\u3067\u3044\u3046 \u3001 504 <\/span>\u756a\u76ee\uff09<\/p>\n

4-3. \u304a\u9152\u306b\u5f31\u304f\u306a\u308bALDH2<\/em>\u306e\u907a\u4f1d\u5b50\u578b<\/h4>\n

\u30d2\u30c8\u306e\u5834\u54082<\/span>\u3064\u306e\u30b2\u30ce\u30e0\u30bb\u30c3\u30c8\u3092\u3082\u3061\u307e\u3059\u3002\u3053\u308c\u306f\u907a\u4f1d\u5b50\u306e\u30bb\u30c3\u30c8\u3092\u4e21\u89aa\u304b\u3089\u305d\u308c\u305e\u308c1<\/span>\u3064\u305a\u3064\u53d7\u3051\u7d99\u3050\u305f\u3081\u3067\u3059\u3002\u305d\u306e\u305f\u3081ALDH2<\/span>\u30822<\/span>\u3064\u3082\u3061\u3001\u5168\u90e8\u30673<\/span>\u30d1\u30bf\u30fc\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u4e21\u65b9\u3001\u9175\u7d20\u6d3b\u6027\u304c\u9ad8\u3044\u907a\u4f1d\u5b50<\/span><\/strong><\/p>\n

\u30fbNN<\/span>\u578b\uff08\u4e21\u65b9\u3001ALDH2<\/span>\u306e\u6d3b\u6027\u578b\uff08N<\/span>\u578b\uff09\uff09<\/p>\n

\u21d2\u304a\u9152\u306b\u5f37\u3044<\/p>\n

\u6d3b\u6027\u306e\u9ad8\u3044\u907a\u4f1d\u5b50\u3068\u4f4e\u3044\u907a\u4f1d\u5b50\u304c\u3072\u3068\u3064\u305a\u3064<\/span><\/strong><\/p>\n

\u30fbND<\/span>\u578b\uff08\u6d3b\u6027\u578bALDH<\/span>\uff12\uff08N<\/span>\u578b\uff09\u3068\u4f4e\u6d3b\u6027\u578bALDH2<\/span>\uff08D<\/span>\u578b\uff09\uff09<\/p>\n

\u21d2\u3042\u308b\u7a0b\u5ea6\u306f\u98f2\u3081\u308b<\/p>\n

\u4e21\u65b9\u3001\u9175\u7d20\u6d3b\u6027\u306e\u4f4e\u3044\u907a\u4f1d\u5b50<\/span><\/strong><\/p>\n

\u30fbDD<\/span>\u578b\uff08\u4e21\u65b9\u3001ALDH2<\/span>\u306e\u4f4e\u6d3b\u6027\u578b\uff08D<\/span>\u578b\uff09\uff09<\/p>\n

\u21d2\u307b\u3068\u3093\u3069\/<\/span>\u5168\u304f\u98f2\u3081\u306a\u3044<\/p>\n

\u00a0\"\"<\/a><\/span><\/p>\n

\u540c\u3058\u91cf\u306e\u9152\u3092\u98f2\u3093\u3060\u5834\u5408\u306e\u8840\u4e2d\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u306f\u3001ND<\/span>\u578b\u306fNN<\/span>\u578b\u306e\u4eba\u306e4<\/span>\uff5e5<\/span>\u500d\u3001DD<\/span>\u578b\u306fNN<\/span>\u578b\u306e\u4eba\u306e20<\/span>\uff5e30<\/span>\u500d\u306b\u306a\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u00a0<\/span>\u907a\u4f1d\u5b50\u306e\u4e2d\u306e\u4e00\u3064\u306e\u5869\u57fa\u304c\u5909\u308f\u308b\u3060\u3051\u3067\u4f5c\u3089\u308c\u308b\u30bf\u30f3\u30d1\u30af\uff08\u9175\u7d20\uff09\u304c\u5909\u308f\u308a\u3001\u7d50\u679c\u3068\u3057\u3066\u4f53\u8cea\u306e\u4e00\u8981\u7d20\u304c\u7570\u306a\u308b\u3082\u306e\u306b\u306a\u308b\u3068\u3044\u3046\u30b1\u30fc\u30b9\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b50\u914d\u5217\u306e\u4e2d\u3067\u7279\u5b9a\u306e\u4e00\u5869\u57fa\u304c\u7570\u306a\u308b\u3082\u306e\u3092SNP<\/span>\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n

4-4. \u4eba\u7a2e\u306b\u3088\u3063\u3066\u3082ALDH2<\/span>\u306e\u578b\u306f\u7570\u306a\u308b<\/h4>\n

\u30d2\u30c8\u306f\u3082\u3068\u3082\u3068\u6d3b\u6027\u578bALDH2<\/em>\u306eNN<\/span>\u578b\u3067\u3057\u305f\u304c\u3001\u6570\u5343\u5e74\u524d\u30b7\u30d9\u30ea\u30a2\u5730\u65b9\u3042\u308b\u3044\u306f\u6771\u30a2\u30b8\u30a2\u3067\u907a\u4f1d\u5b50\u306b\u7a81\u7136\u5909\u7570\u304c\u751f\u3058\u3001\u3053\u308c\u304c\u6771\u30a2\u30b8\u30a2\u306b\u5e83\u304c\u3063\u3066\u3044\u3063\u305f\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u30e8\u30fc\u30ed\u30c3\u30d1\uff65\u30a2\u30d5\u30ea\u30ab\u7b49\u306e\u4eba\u7a2e\u306f\u6b86\u3069NN<\/span>\u578b\u3067\u3001\u30e2\u30f3\u30b4\u30ed\u30a4\u30c9\uff08\u8499\u53e4\u7cfb\u4eba\u7a2e\uff09\u306b\u5c5e\u3059\u308b\u4e2d\u56fd\u3001\u671d\u9bae\u534a\u5cf6\u3001\u65e5\u672c\u3001\u6771\u5357\u30a2\u30b8\u30a2\u5730\u65b9\u306e\u4eba\u7a2e\u306f\u4e00\u5b9a\u306e\u5272\u5408\u3067ND<\/span>\u578b\/DD<\/span>\u578b\u304c\u3044\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002 \u65e5\u672c\u4eba\u3067\u306f\u3001NN<\/span>\u578b\u306e\u4eba\u306f5<\/span>\u5272\u3001ND<\/span>\u578b\u306e\u4eba\u306f4<\/span>\u5272\u3001DD<\/span>\u578b\u306e\u4eba\u306f1<\/span>\u5272\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\uff083<\/span>\uff09\u3002\u6b27\u7c73\u4eba\u306e\u65b9\u304c\u304a\u9152\u306b\u5f37\u3044\u306e\u306fALDH2<\/em>\u306e\u907a\u4f1d\u5b50\u578b\u304c\u5927\u304d\u304f\u304b\u304b\u308f\u3063\u3066\u305d\u3046\u3067\u3059\u306d<\/p>\n

5. ALDH<\/span>\u306e\u578b\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u304a\u9152\u306b\u5f31\u3044\u304b\u5f37\u3044\u304b\u306e\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067\u304d\u308b<\/h3>\n

\"\"<\/p>\n

\u524d\u9014\u306e\u3088\u3046\u306b\u30a2\u30eb\u30b3\u30fc\u30eb\u5206\u89e3\u306b\u95a2\u3059\u308bALDH<\/span>\u306f\u305d\u306e\u907a\u4f1d\u5b50\u914d\u5217\u304b\u3089\u6d3b\u6027\u306e\u9ad8\u3044\u4f4e\u3044\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u30d2\u30c8\u306e\u30b2\u30ce\u30e0\u914d\u5217\u306f2003<\/span>\u5e74\u306b\u5168\u914d\u5217\u306e\u89e3\u8aad\u304c\u7d42\u308f\u3063\u3066\u3044\u307e\u3059\uff084<\/span>\uff09\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8a2d\u8a08\u56f3\u306f\u5206\u304b\u3063\u3066\u3044\u308b\u306e\u3067ALDH<\/span>\u306e\u914d\u5217\u304c\u30b2\u30ce\u30e0\u4e0a\u306e\u3069\u3053\u306b\u3069\u3046\u3044\u3046\u914d\u5217\u3067\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u304b\u306e\u60c5\u5831\u306f\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001\u500b\u3005\u4eba\u306eALDH<\/span>\u306e\u907a\u4f1d\u5b50\u914d\u5217\u304c\u308f\u304b\u308c\u3070\u305d\u306e\u4eba\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u4e88\u6e2c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u30a4\u30fc\u30d3\u30fc\u30a8\u30b9\u682a\u5f0f\u4f1a\u793e\u3055\u307e<\/span>\u306e\u3088\u3046\u306b\u5b9f\u969b\u306fALDH2<\/span>\u306b\u52a0\u3048ADH1<\/span>\u306e\u907a\u4f1d\u5b50\u914d\u5217\u3092\u8abf\u3079\u306e\u30bf\u30a4\u30d7\u306b\u5206\u985e\u3059\u308b\u30b5\u30fc\u30d3\u30b9\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\uff08EBS\u3000\u30a2\u30eb\u30b3\u30fc\u30eb\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u691c\u67fb\u30ad\u30c3\u30c8<\/a>\uff09<\/p>\n

\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u914d\u5217\u304b\u3089\u500b\u3005\u4eba\u306e\u4f53\u8cea\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u3092\u907a\u4f1d\u5b50\u8a3a\u65ad\u3068\u547c\u3073\u307e\u3059\u3002\u3059\u3067\u306b\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u4ee5\u5916\u306b\u3082\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067\u4e88\u6e2c\u3067\u304d\u308b\u4f53\u8cea\u3082\u591a\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n

6. \u907a\u4f1d\u5b50\u578b\u3067\u6c7a\u307e\u3089\u306a\u3044\u8981\u7d20\u3082\u591a\u304f\u3042\u308b<\/h3>\n

\u304a\u9152\u306b\u5f37\u3044\u3001\u5f31\u3044\u306fALDH<\/span>\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\u3067\u4e88\u6e2c\u3067\u304d\u307e\u3059\u304c\u3001\u5b9f\u969b\u306b\u306f\u907a\u4f1d\u5b50\u578b\u3060\u3051\u3067\u6c7a\u307e\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305a\u3001\u3067\u3082\u66f8\u304d\u307e\u3057\u305f\u304c\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u9154\u3046\u3068\u3044\u3046\u73fe\u8c61\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u304b\u308f\u304b\u3089\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u5e74\u9f62\u306b\u3088\u3063\u3066\u3082\u6a5f\u80fd\u306b\u5dee\u304c\u51fa\u307e\u3059\u3002\u4f53\u306e\u5927\u304d\u3055\u306a\u3069\u3082\u304a\u9152\u306e\u5f37\u5f31\u306b\u5f71\u97ff\u3057\u307e\u3059\u3002<\/p>\n

\u5192\u982d\u306b\u4f53\u8cea\u306f\u907a\u4f1d\u306b\u3088\u308b\u5148\u5929\u7684\u306a\u3082\u306e\u3068\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3084\u74b0\u5883\u8981\u56e0\u306e\u3088\u3046\u306a\u5f8c\u5929\u7684\u306a\u3082\u306e\u304c\u5f71\u97ff\u3059\u308b\u3068\u66f8\u304d\u307e\u3057\u305f\u3002\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u8010\u6027\u3082\u305d\u3046\u3067\u3059\u304c\u3001\u907a\u4f1d\u5b50\u8a3a\u65ad\u306e\u7d50\u679c\u304c\u3059\u3079\u3066\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3042\u304f\u307e\u3067\u50be\u5411\u3092\u4e88\u6e2c\u3059\u308b\u3082\u306e\u3068\u3057\u3066\u6d3b\u7528\u3057\u3066\u3044\u304d\u305f\u3044\u3067\u3059\u306d\u3002<\/p>\n

7. \u307e\u3068\u3081<\/h3>\n

\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u8010\u6027\u306fALDH2<\/span>\u3068\u3044\u3046\u9175\u7d20\u306e\u50cd\u304d\u304c\u5927\u304d\u304f\u95a2\u4fc2\u3057\u307e\u3059\u3002ALDH2<\/span>\u3092\u3064\u304f\u308b\u907a\u4f1d\u5b50\u306b\u306f\u591a\u578b\u304c\u3042\u308a\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u5206\u89e3\u80fd\u529b\u304c\u9ad8\u3044\u3068\u3055\u308c\u308b\uff2e\u578b\u5206\u89e3\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u305f\uff24\u578b\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u4e21\u89aa\u304b\u3089\u907a\u4f1d\u5b50\u3092\uff11\u3064\u305a\u3064\u53d7\u3051\u7d99\u3050\u306e\u3067\u3001NN<\/span>\u578b\u3001ND<\/span>\u578b\u3001DD<\/span>\u578b\u306e3<\/span>\u30d1\u30bf\u30fc\u30f3\u306b\u5206\u3051\u3089\u308c\u3001\u540c\u3058\u91cf\u306e\u9152\u3092\u98f2\u3093\u3060\u5834\u5408\u306e\u8840\u4e2d\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u306f\u3001ND<\/span>\u578b\u306fNN<\/span>\u578b\u306e\u4eba\u306e4<\/span>\uff5e5<\/span>\u500d\u3001DD<\/span>\u578b\u306fNN<\/span>\u578b\u306e\u4eba\u306e20<\/span>\uff5e30<\/span>\u500d\u306b\u306a\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u00a01.\u3000<\/span>\u677e\u672c\u660e\u5b50. (2016). <\/span>\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d20 2 (ALDH2) <\/span>\u306e\u69cb\u9020\u30fb\u6a5f\u80fd\u306e\u57fa\u790e\u3068 ALDH2 <\/span>\u907a\u4f1d\u5b50\u591a\u578b\u306e\u91cd\u8981\u6027. <\/span>\u65e5\u672c\u885b\u751f\u5b66\u96d1\u8a8c, 71(1), 55-68.<\/span><\/a><\/p>\n

2.\u3000<\/span>Wang, M. F., Han, C. L., & Yin, S. J. (2009). Substrate specificity of human and yeast aldehyde dehydrogenases.\u00a0Chemico-biological interactions<\/em>,\u00a0178<\/em>(1-3), 36\u201339.<\/a><\/p>\n

3.\u3000\u539f\u7530\u52dd\u4e8c. (1997). <\/span>\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u306e\u907a\u4f1d\u7684\u500b\u4eba\u5dee. <\/span>\u751f\u7269\u7269\u7406\u5316\u5b66, 41(3), 111-116.<\/span><\/a><\/p>\n

4.\u3000International Human Genome Sequencing Consortium. (2004). Finishing the euchromatic sequence of the human genome. Nature, 431(7011), 931-945.<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u30a2\u30ab\u30b7\u30a2\u306e\u6a39Q\uff06A\u30b7\u30ea\u30fc\u30ba\uff5e\u5065\u5eb7\u306b\u95a2\u3059\u308b\u300c\u30a6\u30ef\u30b5\u306e\u771f\u76f8\u300d\uff5e \u7b2c15\u56de\u3000\u30a2\u30eb\u30b3\u30fc\u30eb\u3068\u907a\u4f1d\u5b50\u306b\u95a2\u3059\u308b\u30a6\u30ef\u30b5\u306e\u771f\u76f8 \u4f53\u8cea\u7684\u306b\u307e\u3063\u305f\u304f\u304a\u9152\u304c\u98f2\u3081\u306a\u3044\u3001\u3082\u3057\u304f\u306f\u5c11\u91cf\u3057\u304b\u98f2\u3081\u306a\u3044\u4eba\u306e\u3053\u3068\u3092\uff62\u4e0b\u6238\uff08\u3052\u3053\uff09\uff63\u3068\u547c\u3073\u307e\u3059\u3002\u3053\u306e\u4e0b\u6238\u3068\u3044\u3046\u8a00 […]<\/p>\n","protected":false},"author":24,"featured_media":14557,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"swell_btn_cv_data":"","footnotes":""},"categories":[58],"tags":[],"class_list":["post-14538","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rumor"],"acf":[],"yoast_head":"\n\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u5f37\u3044\u3001\u5f31\u3044\u306f\u907a\u4f1d\u5b50\u306e\u914d\u5217\u306b\u3088\u3063\u3066\u9055\u3046\u3063\u3066\u30a6\u30bd\uff1f\u30db\u30f3\u30c8\uff1f - 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