{"id":13318,"date":"2022-12-23T18:00:29","date_gmt":"2022-12-23T09:00:29","guid":{"rendered":"https:\/\/www.acacia-no-ki.co.jp\/wellness\/?p=13318"},"modified":"2023-12-14T12:55:53","modified_gmt":"2023-12-14T03:55:53","slug":"polymethoxylated-flavonoids","status":"publish","type":"post","link":"https:\/\/www.acacia-no-ki.co.jp\/wellness\/polymethoxylated-flavonoids\/","title":{"rendered":"\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u4e00\u7a2e\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306f\u6a39\u76ae\u304b\u3089\u62bd\u51fa\u3055\u308c\u308b\u3063\u3066\u3001\u30a6\u30bd\uff1f\u30db\u30f3\u30c8\uff1f"},"content":{"rendered":"

\u4eca\u5e74\u5ea6\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5b66\u4f1a\u306f3<\/span>\u5e74\u3076\u308a\u306e\u73fe\u5730\u958b\u50ac\u3067\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3084\u7279\u5225\u8b1b\u6f14\u3092\u5408\u308f\u305b\u308b\u3068\u53e3\u982d\u3067\u306e\u8b1b\u6f14\u306f8<\/span>\u6f14\u984c9<\/span>\u3064\u306e\u767a\u8868\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30dd\u30b9\u30bf\u30fc\u3067\u306e\u767a\u8868\u306b\u95a2\u3057\u3066\u306f29<\/span>\u6f14\u984c\u306e\u767a\u8868\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u305d\u306e\u4e2d\u306e\u3044\u304f\u3064\u304b\u306e\u6f14\u984c\u3092\u7d39\u4ecb\u3001\u89e3\u8aac\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5b66\u4f1a\u306e\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u2161\u3067\u306f\u300c\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\uff5e\uff30\uff2d\uff26\u306e\u591a\u69d8\u6027\uff5e\u300d\u3068\u984c\u3057\u3066\u6700\u8fd1\u6ce8\u76ee\u3092\u96c6\u3081\u308b\uff30\uff2d\uff26\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9:<\/span>\u3000polymethoxylated flavonoids<\/span>\u306b\u3064\u3044\u3066\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u6a5f\u80fd\u89e3\u6790\u3084\u5fdc\u7528\u9762\u3067\u306e\u7814\u7a76\u6210\u679c\u306a\u3069\u69d8\u3005\u306a\u767a\u8868\u304c\u3042\u308a\u307e\u3057\u305f\uff081\uff09\u3002<\/p>\n

\u300c\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u4e00\u7a2e\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306f\u6a39\u76ae\u304b\u3089\u62bd\u51fa\u3055\u308c\u308b\u300d\u3063\u3066\u3001\u30a6\u30bd\uff1f\u30db\u30f3\u30c8\uff1f<\/span>
\n(\u8cea\u554f\u306b\u5bfe\u3059\u308b\u30a2\u30f3\u30b5\u30fc\u306b\u3064\u3044\u3066\u306f\u30a2\u30ab\u30b7\u30a2\u306e\u6a39\u516c\u5f0f\u30c4\u30a4\u30c3\u30bf\u30fc\u306b\u3066\u30a2\u30f3\u30b1\u30fc\u30c8\u5f62\u5f0f\u3067\u6295\u7968\u3067\u304d\u307e\u3059\u3002\u30b3\u30c1\u30e9\u304b\u3089\u3002<\/a>)
\n<\/strong><\/p>\n

\u30a6\u30bd\uff08\u4fe1\u983c\u6027\u2605\u2605\u2605\u2605\u2606\uff09\uff1a \u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306f\u6a39\u76ae\u304b\u3089\u62bd\u51fa\u3055\u308c\u308b\u6210\u5206\u3067\u306f\u306a\u304f\u4e3b\u306b\u67d1\u6a58\u306e\u679c\u76ae\u306b\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u9ed2\u30a6\u30b3\u30f3\u3084\u9ed2\u30b7\u30e7\u30a6\u30ac\u306a\u3069\u306b\u3082\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

1. \uff30\uff2d\uff26\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3068\u306f\u3069\u3093\u306a\u6210\u5206\uff1f<\/strong><\/h4>\n

\uff30\uff2d\uff26\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3063\u3066\u805e\u304d\u306a\u308c\u306a\u3044\u3067\u3059\u3088\u306d\u3002\u4f55\u304b\u96e3\u3057\u305d\u3046\u3068\u611f\u3058\u305f\u4eba\u3082\u591a\u3044\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\u5927\u4e08\u592b\u3067\u3059\u3002\u308f\u304b\u308a\u3084\u3059\u304f\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306f\u5358\u4e00\u6210\u5206\u306e\u540d\u79f0\u3067\u306f\u306a\u304f\u8907\u6570\u6210\u5206\u306e\u7dcf\u79f0\u3067\u3059\u3002\u81ea\u7136\u754c\u306b\u306f5000-8000<\/span>\u7a2e\u985e\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u304c\u3042\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\uff0811\u670826\u65e5\u306f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u65e5\u3063\u3066\u30a6\u30bd\uff1f\u30db\u30f3\u30c8\uff1f<\/a>\uff09\u3002\u3053\u306e\u3042\u305f\u308a\u306e\u3053\u3068\u306f\u5148\u65e5\u653e\u9001\u3055\u308c\u305f\u30c1\u30b3\u3061\u3083\u3093\u306b\u53f1\u3089\u308c\u308b\u3067\u3082\u53d6\u308a\u4e0a\u3052\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\uff08NHK\u756a\u7d44\u300c\u30c1\u30b3\u3061\u3083\u3093\u306b\u53f1\u3089\u308c\u308b\u300d<\/a><\/span>\uff09\u305d\u306e\u7a2e\u985e\u306f\u69cb\u9020\u306e\u7279\u5fb4\u304b\u3089\u3044\u304f\u3064\u304b\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u5927\u304d\u306a\u5206\u985e\u3067\u306f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u578b\u304b\u975e\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u578b\u3067\u3059\uff08\u56f31\uff09\u3002\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u57fa\u672c\u69cb\u9020\u306f\uff12\u3064\u306e\u30d9\u30f3\u30bc\u30f3\u74b0\u304c3<\/span>\u3064\u306e\u70ad\u7d20\u3067\u3064\u306a\u304c\u308c\u3066\u3044\u308bC6-C3-C6<\/span>\u69cb\u9020\u304c\u57fa\u672c\u9aa8\u683c\u3067\u3059\uff08\u56f31<\/span>\uff09\u3002<\/p>\n

\"\"<\/p>\n

\u305d\u306e\u3046\u3061\u6c34\u9178\u57fa\uff08OH<\/span>\uff09\u306e\u4ee3\u308f\u308a\u306b\u3001\u30e1\u30c8\u30ad\u30b7\uff08OCH3<\/span>\uff09\u57fa\u304c\u7f6e\u63db\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u304c\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\uff08PMF<\/span>\uff53\u3000polymethoxylated flavonoids<\/span>\uff09\u3067\u3059\uff08\u56f32<\/span>\uff09<\/p>\n

\"\"<\/p>\n

2. PMFs\u304c\u591a\u304f\u542b\u307e\u308c\u308b\u690d\u7269\u3092\u7d39\u4ecb<\/span><\/strong><\/h4>\n

PMF\uff53\u306f\u67d1\u6a58\u306e\u679c\u76ae\u306b\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u304c\u76db\u3093\u306a\u6210\u5206\u3068\u3057\u3066\u306f\u30b7\u30fc\u30af\u30ef\u30a2<\/sub>\u30fc\u30b5\u30fc\u306e\u679c\u76ae\u306b\u542b\u307e\u308c\u308b\u30ce\u30d3\u30ec\u30c1\u30f3\u3067\u3059\u3002\u30dd\u30f3\u30ab\u30f3\u306e\u76ae\u306b\u3082\u542b\u307e\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u9ed2\u30a6\u30b3\u30f3\u3084\u9ed2\u30b7\u30e7\u30a6\u30ac\u306a\u3069\u306b\u3082\u591a\u304f\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\uff081, 2<\/span>\uff09\u67d1\u6a58\u306f\u6e29\u6696\u306a\u5730\u57df\u3067\u751f\u7523\u304c\u76db\u3093\u3067\u702c\u6238\u5185\u6d77\u306b\u9762\u3057\u305f\u5730\u57df\u3067\u3082\u591a\u304f\u4f5c\u3089\u308c\u307e\u3059\u3002\u672c\u793e\u304c\u5e83\u5cf6\u306b\u3042\u308b\u30a2\u30ab\u30b7\u30a2\u306e\u6a39\u3068\u3057\u3066\u3082\u6ce8\u76ee\u306e\u6210\u5206\u3067\u3059\u3002PMF<\/span>\uff53\u306e\u52b9\u679c\u3068\u3057\u3066\u306f\u6297\u9178\u5316\u3001\u6297\u708e\u75c7\u6297\u30e1\u30bf\u30dc\u8a18\u61b6\u969c\u5bb3\u6539\u5584\u3001\u809d\u6a5f\u80fd\u6539\u5584\u306a\u3069\u52b9\u679c\u304c\u3042\u308a\u69d8\u3005\u306a\u5927\u5b66\u3084\u4f01\u696d\u3067\u3082\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

3. PMF\u306f\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u4f38\u306b\u3064\u306a\u304c\u308b\uff1f\uff1f\uff1f<\/span><\/strong><\/h4>\n

\"\"<\/p>\n

\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u306e\u6c38\u7530\u5b8f\u6b21\u6559\u6388\u3089\u306f\u3001PMF<\/span>\u306e\u6700\u65b0\u306e\u7814\u7a76\u7d50\u679c\u306b\u3064\u3044\u3066Nature\u306e\u59c9\u59b9\u7d19\u3067\u3042\u308bcommunication biology\u306b\u767a\u8868\u3057\u3001\u4eca\u56de\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5b66\u4f1a\u306b\u304a\u3044\u3066\u3082\u305d\u306e\u7814\u7a76\u5185\u5bb9\u3092\u767a\u8868\u3057\u307e\u3057\u305f\uff083, 4<\/span>\uff09\u3002\u6c38\u7530\u6559\u6388\u3089\u306f\u3001\u9ed2\u30a6\u30b3\u30f3\u7531\u6765PMF<\/span>\u304c\u76f4\u63a5\u3001\u9577\u5bff\u907a\u4f1d\u5b50\u7531\u6765\u306e\u9175\u7d20\u300cSIRT1\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\uff11\uff09\u300d\u306b\u7d50\u5408\u3057\u305d\u306e\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u9175\u7d20(SIRT1)<\/span>\u306f\u57fa\u8cea(Ac-p53<\/span>\u30da\u30d7\u30c1\u30c9)<\/span>\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u6a5f\u80fd\u3057\u307e\u3059\u304c\u3001PMF<\/span>\u3068\u7d50\u5408\u3057\u305f\u9175\u7d20(SIRT1)<\/span>\u306f\u3088\u308a\u57fa\u8cea(Ac-p53<\/span>\u30da\u30d7\u30c1\u30c9)<\/span>\u3068\u7d50\u5408\u3057\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\uff08\u57fa\u8cea\u3068\u306e\u89aa\u548c\u6027\u304c\u5411\u4e0a\u3057\u3066\u3044\u307e\u3057\u305f\uff09\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3053\u306e\u7814\u7a76\u3067\u306fPMF<\/span>\u304cSIRT1<\/span>\u306e\u3069\u3053\u306b\u7d50\u5408\u3059\u308b\u306e\u304b\u3001\u307e\u305f\u3001\u5b9f\u969b\u306b\u7d50\u5408\u3057\u305fSIRT1<\/span>\u306e\u6d3b\u6027\u304c\u5897\u5f37\u3057\u3066\u3044\u308b\u304b\u307e\u3067\u8abf\u3079\u3066\u3044\u307e\u3059\u3002\u3053\u306eSIRT1<\/span>\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u52b9\u679c\u306f\u3059\u3067\u306b\u30d6\u30c9\u30a6\u679c\u76ae\u3084\u8d64\u30ef\u30a4\u30f3\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3067\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u9ed2\u30a6\u30b3\u30f3\u7531\u6765PMF<\/span>\u306e\u65b9\u304c6<\/span>\u500d\u52b9\u679c\u7684\u306b\u6d3b\u6027\u5316\u3055\u305b\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u56de\u3053\u306e\u7814\u7a76\u306f\u30d3\u30c8\u30ed\uff08\u8a66\u9a13\u7ba1\u30ec\u30d9\u30eb\u3067\u306e\u8a66\u9a13\uff09\u3084\u30d2\u30c8\u57f9\u990a\u7d30\u80de\u3067\u306e\u8a66\u9a13\u3067\u3059\u304c\u3001\u6c38\u7530\u6559\u6388\u3089\u306f\u4eca\u56de\u306e\u7d50\u679c\u306f\u98df\u306b\u3088\u308b\u5065\u5eb7\u5bff\u547d\u306e\u4f38\u9577\u306b\u8ca2\u732e\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u308b\u3068\u30b3\u30e1\u30f3\u30c8\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u30dd\u30b9\u30bf\u30fc\u767a\u8868\u3067\u306f\u69d8\u3005\u306a\u67d1\u6a58\u985e\u306e\u679c\u76ae\u62bd\u51fa\u7269\u3068SIRT1<\/span>\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3082\u8abf\u3079\u3066\u304a\u308a\u3001\u305d\u306e\u7d50\u679c28<\/span>\u7a2e\u985e\u306e\u679c\u76ae\u306e\u3046\u306110<\/span>\u7a2e\u985e\u306fSIRT1<\/span>\u3092\u6d3b\u6027\u5316\u3057\u3001\u4e00\u65b9\u30673<\/span>\u7a2e\u985e\u306f\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u65b9\u5411\u306b\u50cd\u3044\u305f\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\uff084, 5\uff09\u3002<\/p>\n

\u00a0<\/span><\/p>\n

4. \u307e\u3068\u3081<\/span><\/strong><\/h4>\n

\u4eca\u56de\u306f\uff30\uff2d\uff26\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306b\u3064\u3044\u3066\u306e\u6700\u65b0\u306e\u7814\u7a76\u3092\u304a\u4f1d\u3048\u3057\u307e\u3057\u305f\u3002\u9ed2\u30a6\u30b3\u30f3\u7531\u6765PMF<\/span>\u304c\u76f4\u63a5\u3001\u9577\u5bff\u907a\u4f1d\u5b50\u7531\u6765\u306e\u9175\u7d20\u300cSIRT1\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\uff11\uff09\u300d\u306b\u7d50\u5408\u3057\u305d\u306e\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u3068\u3044\u3046\u5185\u5bb9\u3067\u3057\u305f\u304c\u3001\u3059\u3053\u3057\u96e3\u3057\u304b\u3063\u305f\u3067\u3057\u3087\u3046\u304b\uff1f\u4eca\u56de\u7d39\u4ecb\u3057\u305f\u7814\u7a76\u306f\u9ed2\u30a6\u30b3\u30f3\u3084PMF<\/span>\u3092\u6442\u308c\u3070\u5bff\u547d\u304c\u5ef6\u3073\u308b\u3068\u3044\u3046\u7814\u7a76\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u79d1\u5b66\u7684\u306b\u306f\u91cd\u8981\u306a\u7814\u7a76\u3067\u3042\u308a\u3001\u3053\u3046\u3057\u305f\u57fa\u790e\u7814\u7a76\u304c\u7a4d\u307f\u91cd\u306a\u308b\u3053\u3068\u3067\u79c1\u305f\u3061\u306e\u751f\u6d3b\u306f\u3088\u308a\u826f\u304f\u306a\u3063\u3066\u3044\u304f\u3082\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u8a18\u4e8b\u304c\u5c11\u3057\u3067\u3082\u307f\u306a\u3055\u307e\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u7814\u7a76\u306e\u8208\u5473\u306b\u3064\u306a\u304c\u308c\u3070\u3068\u5b58\u3058\u307e\u3059\u3002<\/p>\n

\u00a0<\/span><\/p>\n

\u3010\u30b3\u30e9\u30e0\u3011\u9577\u5bff\u907a\u4f1d\u5b50<\/em>SIRT1<\/em>\u3063\u3066\u4f55<\/span>\uff1f\u3061\u3087\u3063\u3068\u8a73\u3057\u304f\u8aac\u660e<\/h4>\n

\u9577\u5bff\u907a\u4f1d\u5b50\u7531\u6765\u306e\u9175\u7d20\u300c\uff08\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\uff11\uff09\u300d<\/p>\n

\"\"<\/p>\n

\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3SIRT<\/em>\u907a\u4f1d\u5b50\u306f\u3001\u9577\u5bff\u907a\u4f1d\u5b50\u3084\u6297\u8001\u5316\u907a\u4f1d\u5b50\u3068\u3082\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u907a\u4f1d\u5b50\u304b\u3089\u4f5c\u3089\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6b63\u4f53\u306f\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u3067\u3059\u3002\u751f\u7269\u306e\u7d30\u80de\u306b\u306f\u907a\u4f1d\u60c5\u5831\u306e\u8a70\u307e\u3063\u3066\u3044\u308b\u6838\u3068\u3044\u3046\u5c0f\u5668\u5b98\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u60c5\u5831\u306e\u672c\u4f53\u306fDNA<\/span>\u3068\u547c\u3070\u308c\u308b\u7269\u8cea\u3067\u3059\u304c\u3001DNA<\/span>\u306f\u30d2\u30b9\u30c8\u30f3\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5dfb\u304d\u4ed8\u304d\u30b3\u30f3\u30d1\u30af\u30c8\u306b\u6298\u308a\u305f\u305f\u307e\u308c\u3066\u3044\u307e\u3059\u3002\uff08DNA<\/span>\u304c\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u3082\u306e\u304c\u67d3\u8272\u4f53\u3067\u3059\uff09<\/p>\n

\u3053\u306e\u5dfb\u304d\u4ed8\u304d\u65b9\u3092\u8abf\u7bc0\u3059\u308b\u50cd\u304d\u306e\u4e00\u3064\u306b\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u306e\u72b6\u614b\u3092\u5909\u3048\u308b\u3053\u3068\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u8abf\u7bc0\u3068\u547c\u3073\u307e\u3059\u3002\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3SIRT1\u306f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u8abf\u7bc0\u306b\u3088\u308a\u30d2\u30b9\u30c8\u30f3\u3068DNA<\/span>\u306e\u7d50\u5408\u306b\u4f5c\u7528\u3057\u3001\u907a\u4f1d\u7684\u306a\u8abf\u7bc0\u3092\u884c\u3046\u3053\u3068\u3067\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

1.\u3000Nogata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M, Ohta H. Flavonoid composition of fruit tissues of citrus species. Biosci Biotechnol Biochem. 2006 Jan;70(1):178-92<\/a>.<\/p>\n

2.\u3000\u304b\u3089\u3060\u30b5\u30dd\u30fc\u30c8\u7814\u7a76\u6240\u3000\u30dd\u30ea\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3092\u542b\u3080\u67d1\u6a58<\/a><\/p>\n

3.\u3000Zhang M, Lu P, Terada T, Sui M, Furuta H, Iida K, Katayama Y, Lu Y, Okamoto K, Suzuki M, Asakura T, Shimizu K, Hakuno F, Takahashi SI, Shimada N, Yang J, Ishikawa T, Tatsuzaki J, Nagata K. Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1. Commun Biol. 2021 Feb 19;4(1):209.<\/a><\/p>\n

4.\u3000\u6c38\u7530\u5b8f\u6b21\u3000\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306b\u3088\u308b\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20SIRT1<\/span>\u306e\u6d3b\u6027\u4e0a\u6607\u306e\u5206\u5b50\u6a5f\u69cb\u89e3\u6790\u3068\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\u3000\u65e5\u672c\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5b66\u4f1a\u3000\u7b2c15<\/span>\u56de\u5b66\u8853\u96c6\u4f1a\u3000\u30d7\u30ed\u30b0\u30e9\u30e0\u6284\u9332\u96c6\u3000p14<\/span><\/p>\n

5.\u3000\u67ef\u878d\u3001\u5965\u7530\u5091\u3001\u52a0\u85e4\u4e45\u5247\u3001\u6c38\u7530\u5b8f\u6b21\u3000\u67d1\u6a58\u985e\u679c\u76ae\u4e2d\u306eSIRT<\/span>\uff11\u6d3b\u6027\u5316\u304a\u3088\u3073\u963b\u5bb3\u7269\u8cea\u306e\u540c\u5b9a\u3000\u65e5\u672c\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5b66\u4f1a\u3000\u7b2c15<\/span>\u56de\u5b66\u8853\u96c6\u4f1a\u3000\u30d7\u30ed\u30b0\u30e9\u30e0\u6284\u9332\u96c6\u3000p31<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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